Polynucleotides in Guildford, Surrey
Contact Us TodayTreatment Overview
Treatments
Two or three (depending on patient need)
Procedure time
45-60 minutes
Price
From £350
Anaesthetic
Yes
Duration of results
Around 6 to 9 month
Recovery time
Up to one week
Walking and gentle daily activities are fine.
No heavy exercise for 24 hours.
No make up for 24 hours.
Results
Results start to become visible at around 3-4 weeks and are optimal at 4 weeks after the second or third treatment
Discomfort level
Low
What are polynucleotides?
Polynucleotides are advanced biostimulators derived from DNA fragments that work beneath the skin’s surface. Unlike traditional dermal fillers, polynucleotides don’t add volume—they kickstart your skin’s own repair mechanisms by stimulating collagen production, boosting fibroblast activity, improving elasticity, and reducing inflammation.
How do polynucleotides work?
Polynucleotides:
- Bind to water molecules, promoting deep hydration.
- Trigger natural collagen and elastin synthesis for firmer tissue.
- Calm redness and inflammation by supporting cellular regeneration.
This unique mode of action makes polynucleotides a versatile option for total skin rejuvenation.
The polynucleotides are distilled into a range of strengths and suspended in water for injection. They are injected into the superficial layer of the skin. The clinician uses either a fine needle or a cannula to administer multiple micro-doses into the target area. A course of three or four treatments 3 weeks apart is recommended to achieve optimum results. At Optimise Aesthetics, we use only FDA-approved brands, including Plinest, Plenhyage XL, Nucleadyn and Polynucleotides to allow for maximum safety and natural results. The results are not instant but improvement can be noted from about three weeks and continues to improve over a twelve week period.
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Benefits of Polynucleotides
- Visible reduction in fine lines and wrinkles Improved skin texture and elasticity
- Diminished dark circles and puffiness around eyes
- Calmed redness and evened skin tone
- Accelerated healing of acne scars, stretch marks, and surgical scars
- Enhanced scalp health and hair growth
Popular treatment zones for polynucleotides:
Polynucleotide injections can be tailored to any area of the body. Popular treatment zones include:
- Perioral “smoker’s” lines
- Delicate under-eye area (dark circles, fine lines)
- Cheeks and nasolabial folds
- Neck and décolletage
- Acne and surgical scars
- Stretch marks on abdomen, thighs, or arms
- Scalp for hair density and scalp health
Polynucleotides are not just suitable for the face – they are an effective treatment option for any part of the body. Polynucleotides can now also be combined with fillers as a hybrid product to boost filler results. At Optimise Aesthetics, if we think that this will be the best option for you, we will recommend a hybrid treatment, and will ultimately do whatever you feel most comfortable with.
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Before and After
Frequently Asked Questions
What do polynucleotides do to your skin?
Polynucleotides are biostimulatory DNA fragments that trigger fibroblast activity, boosting collagen and elastin production while binding water for deep hydration. Over 4–12 weeks, they improve skin texture, firmness, and elasticity, leading to smoother, more resilient skin.
Are polynucleotides safe?
Yes. They’re produced by licensed manufacturers under strict regulation, purified to remove proteins, and sterilised to meet CE safety standards—so allergic reactions are virtually eliminated.
Numerous peer-reviewed studies back their safety and effectiveness in both medical tissue repair and aesthetic treatments, with no known risks from injecting exogenous polynucleotides.
We’ll also walk you through any temporary side effects—such as mild redness or swelling—so you know exactly what to expect.
Are polynucleotides better than fillers?
Polynucleotides act as regenerative injectables, stimulating your own collagen and elastin over time, whereas dermal fillers immediately restore volume by physically filling creases. For overall skin health and subtle rejuvenation, polynucleotides excel; for instant volume and contour, fillers remain unmatched.
Are there any downsides to polynucleotides?
While generally well tolerated, polynucleotide treatments can cause temporary redness, swelling, and bruising at injection sites. Rarely, patients may experience mild allergic reactions or small nodules, underscoring the importance of a qualified injector and proper aftercare.
Which is better, Profhilo or polynucleotides?
Profhilo leverages high- and low-molecular-weight hyaluronic acid for rapid hydration and firmness, showing results within days but requiring maintenance every 3–4 months. Polynucleotides work at a deeper cellular level to regenerate skin structure, with results emerging over 4–12 weeks and lasting up to 6–12 months.
Do polynucleotides work under eyes?
Yes. Polynucleotides hydrate the delicate under-eye area, enhance microcirculation, and stimulate collagen/elastin production to reduce dark circles, fine lines, and crepe-like skin. Clinical studies report visible under-eye brightening and improved skin quality after two to three sessions.
Which is better, microneedling or polynucleotides?
Microneedling creates micro-injuries to kickstart collagen synthesis and improve product absorption, but pairing it with polynucleotides (“polyneedling”) delivers regenerative DNA fragments deep into the dermis. This combo maximises collagen stimulation, hydration, and overall rejuvenation for firmer, smoother skin.
Who cannot have polynucleotides?
Polynucleotide treatments aren’t recommended for pregnant or breastfeeding women, individuals with fish allergies (as the DNA is fish-derived), those with active skin infections, and patients with severe autoimmune disorders. A full medical history and allergy check are essential prior to treatment.
Will one session of polynucleotides work?
While a single session can boost hydration and provide a mild collagen stimulus, optimal results usually require two to three treatments spaced 2–4 weeks apart. This course length ensures cumulative collagen remodelling and lasting improvements in skin quality.
Will polynucleotides get rid of wrinkles?
By stimulating endogenous collagen and elastin synthesis, polynucleotides progressively soften fine lines and wrinkles. Although they don’t erase deep folds as fillers do, repeated sessions yield smoother, more youthful-looking skin over 8–12 weeks
How painful are polynucleotide injections?
Most patients report only mild discomfort or a stinging sensation during polynucleotide injections, especially in sensitive areas. Topical numbing creams can minimise pain, and any tenderness typically subsides within a few hours.
Can polynucleotides help with marionette lines?
Polynucleotides enhance skin thickness, elasticity, and hydration around the mouth, helping to soften marionette lines. For deeper folds, combining them with fillers or tightening procedures often delivers more dramatic results.
What to avoid after polynucleotides?
Avoid strenuous exercise, excessive heat (saunas, sunbathing), alcohol, and active skincare ingredients (AHAs, retinoids) for 48 hours. Also, skip heavy makeup and don’t rub or massage the treated area to allow optimal absorption and healing.
Will I bruise after polynucleotides?
Bruising can occur, especially in thin or sensitive skin, but it’s usually mild and resolves within a few days. Applying arnica or vitamin K cream and avoiding blood-thinning substances can help minimise and speed up bruise healing.
What is the aftercare for polynucleotides?
After your treatment, you may notice small bumps (settle in 3–12 hours), redness, swelling (peaks around 24 hours, resolves by 48 hours) or bruising (appears day 2, fades in 10–14 days). To minimise side effects:
- For the first 6 hours, avoid makeup, tight headgear, touching or scratching the area, pressing your phone against it, and letting pets near your face.
- For the first 24 hours, skip aspirin, alcohol, extreme heat or cold, and vigorous exercise.
- Apply brief cold compresses (wrapped in a cloth) and use arnica or bromelain for bruising if needed.
- If symptoms worsen after 12 hours, contact the clinic.
- Schedule your follow-up appointment in about three weeks.
What Our Clients Have to Say
“I have polynucleotide treatments around every six months. I have it for all around the eye area and a little bit down the sides of my face and around my mouth. The polynucleotides are an amazing treatment because it makes your skin make its own collagen and it really freshens the eye area up. It takes a bit of a time to show up but when it does, you catch yourself and think, wow, it has really made a big difference.”
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